Underplayed Gems

S.E.M.I. – Side Effects May Include... (2026)

S.E.M.I. – Side Effects May Include... cover
Developer
Two Horn Unicorn
Platforms
Windows
Genres
Action, Indie
Rating
4.3 of 5, 111 player ratings
Typical playtime
about 2.0 hours
Where to get it
Steam
The 3D catalog: game boxes on wooden shelves, with the cat sitting at the counter next to its greeting.

The catalog in 3D

The same catalog has a room you can walk around in. The cat behind the counter is the AI Catbot, and they pick real games from it when you tell them what you feel like playing. Nothing is for sale, here or in there. Go in from here and this game is already out on the counter, with more like it waiting on the shelf next to it.

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How it feels

A brisk, modern action game with arcade-style movement and clean visual feedback.

actionfast-pacedindiearcade-likeenergeticmodernside-scrolling

What players say

Players recommend it for co-op chaos and silly pill-based abilities, but warn that motion blur cannot be fully disabled and the campaign is only about an hour long.

Screenshots

S.E.M.I. – Side Effects May Include... screenshot 1S.E.M.I. – Side Effects May Include... screenshot 2S.E.M.I. – Side Effects May Include... screenshot 3S.E.M.I. – Side Effects May Include... screenshot 4S.E.M.I. – Side Effects May Include... screenshot 5S.E.M.I. – Side Effects May Include... screenshot 6

More games like this

This page is from Underplayed Gems, a catalog of older and overlooked games. Not quite it? You can browse by platform and genre, or take this one into the 3D catalog and ask the Catbot for something closer.